Girl from the South follows Gillon Stokes, a young woman from Charleston, South Carolina, who travels to London to escape the conservative expectations of her Southern upbringing. Gillon is intelligent, independent, and somewhat out of place in her traditional family, which still holds rigid ideas about femininity, marriage, and social roles.

In London, she meets Tash, an ambitious and modern British woman working in photography, and Henry, a gentle and sensitive man from a large, emotionally complex family. Gillon becomes deeply involved in their lives, and through these relationships, the novel explores cultural contrasts between the American South and modern urban Britain.

As Gillon navigates friendship, love, and family tensions, she is forced to question her own identity and values. The novel shifts between London and Charleston, revealing how different worlds handle love, gender roles, and family obligations.